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Summary
Luciana is speaking with S. Antipholus, counseling him to be more cunning with regard to his character around Adriana. Specifically, Luciana tells Antipholus that if he is cheating on his wife, he should make more of an effort to deceive her, to at least make her feel as though he still loves only her. S. Antipholus professes that he understands nothing of what she is saying, as Adriana is most definitely not his wife and that he is in fact enamored of Luciana herself. Luciana protests that he is being ridiculous, as he must love only his wife, but S. Antipholus insists that he is interested in Luciana alone.
When Luciana leaves to get Adriana, S. Dromio appears to lament that he is being claimed by a woman named Nell (who is understood to be Luce, from act 2, scene 2). He is especially upset by this situation because Nell is quite obese, as his exaggerated comments regarding her girth indicate. S. Dromio makes a number of insulting comparisons between nations and parts of her body. When Nell proves able to tell Dromio about the various marks on his body, he begins to think she is some sort of witch. S. Antipholus then suggests to S. Dromio that he go wait by the harbor; if a seaward wind comes along and a ship is sailing out, S. Dromio should find S. Antipholus in the marketplace, and they will leave immediately. When S. Dromio leaves, S. Antipholus declares his own belief that they are among witches - but also that he will regret leaving Luciana.
Angelo then appears and insists upon giving S. Antipholus the chain that E. Antipholus had ordered. S. Antipholus eventually accepts and tries to pay for it then rather than later, so as not to accidentally cheat the man, but Angelo departs without accepting. S. Antipholus notes that only in such a strangely wonderful place would people bestow random gifts upon him.